Which of the Following Are Most Susceptible to Complement Lysis

C3 is the most abundant complement protein in plasma occurring at a concentration of 12 mg ml 1 and up to 1000 molecules of C3b can bind in the vicinity of a single active C3 convertase see Fig. C3b binds covalently through its thioester bond to adjacent molecules on the pathogen surface.

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Lymphocytes that mature in the bone marrow are called T cells.

. Experimental studies showed that complement can be activated by amastigote Iida et al 1989 epimastigote Nogueira et al 1975 and trypomastigote forms Kipnis et al 1985 but only non-infective epimastigote forms are susceptible to complement lysis. Which of the following are most susceptible to complement lysis. Otherwise it is inactivated by hydrolysis.

It forms a transmembrane channel which causes osmotic lysis of the target cell. Red cells which have antibody bound to the cell surface can also activate the classical and lytic pathways and become susceptible to lysis. Lymphocytes are the cells primarily responsible for the specific immune responses.

Most gram-negative bacteria are susceptible to complement-mediated lysis whereas most gram-positive bacteria cannot be penetrated. Which of the following are most susceptible to complement lysis. Role of Complement in Disease.

Thus the main effect of complement. Furthermore we confirmed that the major sporozoite surface antigen CSP is an important target of complement fixation demonstrated using multiple cohort studies of malariaendemic populations7 There is also evidence that nonCSP antibodies play a role but the specific antigenic targets are yet to be identified47 Previous studies of the murine and avian. MAC is the cytolytic endproduct of the complement cascade.

This method uses physical penetration to pierce or cut a cell membrane. Which of the following are most susceptible to complement lysis. Though this method usually comes out clean it fails to be cost effective and consistent.

The complex resulting from complement activity that leads to cell lysis is the A. This method uses ultrasonic waves to generate areas of high and low pressure which causes cavitation and in turn cell lysis. C6 C7 C8 and C9 unite with C5b and this membrane-attack complex MAC when inserted into the outer membrane of some bacteria can contribute to their death by lysis.

Additionally most enveloped viruses are susceptible to complement-mediated lysis. Kupffer cells and other macrophage cell types help clear complement-coated pathogens. Which of the following are most susceptible to complement lysis.

Gram-negative bacteria are less susceptible to complement lysis than Gram-positive bacteria.

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